*Lesson 18: Serial Passage Theory

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Serial passage is a technique used to develop a mutated form of a virus—hopefully a weaker strain of a virus so that it may be used to create a vaccine.  Louis Pasteur developed the serial passage technique— infecting an organism with a virus, allowing it to incubate and perhaps mutate, and then another organism is infected with the incubated virus.  This infection-incubation process is repeated accordingly. Pasteur used the serial passage technique to produce vaccines for example a rabies vaccine.

The Serial Passage Theory is named after this technique because the theory asserts that SIV mutated to HIV through unintended consequences of a vaccination program that allowed for the infection-incubation process to occur.

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